Panaceia or Hygeia

immunize yourself against the pandemic of lifestyle diseases

Regression of Coronary Plaque by Medical Therapy

Posted by Colin Rose on April 5, 2017

Here is a very clear demonstration that invasive revascularization is not necessary in stable coronary atherosclerosis in the absence of disabling symptoms. There is no data about the patients lifestyle or BMI before therapy that might have explained his hyperlipidemia. If an obvious self destructive atherogenic lifestyle had been present I would have initially tried lifestyle change before statins and ezetimibe.


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98% of very high cholesterol is not caused by mutations in the genetic code, another blow to the hype of the genome sequencing industry. 

Posted by Colin Rose on April 5, 2016

For more than 30 years  the mantra of the cholesterol industry has held that “high cholesterol” in the general population is caused by a genetic abnormality which must be “treated” with a drug, usually a statin, because lifestyle change would be largely futile. There was great hope that by sequencing the genome we could find a coding gene that would give us the key to eliminating atherosclerosis, the cause of heart attacks. But a recent publication in The Journal of the American College of Cardiology shows that only 1.7% of very high cholesterol can be explained by mutation of genes known to code for proteins involved in cholesterol metabolism. So what is  going on?

Variables like the blood concentrations of many metabolites and the intercellular concentrations of gene controlled products like RNA and proteins are largely related to environmentally influenced variation in the expression of normal genes, not mutations of the genes themselves.

An example of a disease truly caused by an abnormal coding gene is sickle cell anemia which has long been known to be caused by a mutation of just one of the millions of base pairs in the DNA code with no significant environmental influence.

But less than 2% of our DNA is used to code for proteins that form skin, blood, muscle, etc. The other 98% of our DNA, what used to be called junk DNA, is composed of code that regulates the protein coding DNA and is very sensitive to environmental influences like diet, smoking, drugs, exercise, weather, air pollution, etc. How this non-coding DNA is influenced by the environment and how it controls the expression of coding DNA is very mysterious.  It will be a long time before we have a precise mathematical model of the thousands of self referential pathways involved in gene regulation. In the meanwhile we have pretty good evidence for which environments are healthy and that influencing gene expression in this manner is much more important than prescribing drugs to “treat” just one of the results of the alteration of gene expression like high cholesterol.

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Geneticist Cures His Own Type 2 Diabetes by Changing his Lifestyle not his Genes

Posted by Colin Rose on April 15, 2012

This story in Science Now, a vehicle published by the AAAS for vulgarization of  basic science, is a classic example of the hype surrounding gene sequencing and gene expression. To judge from this headline any reader would assume that the cure for Type 2 diabetes was simply to measure genes and gene expression. However when one reads the actual publication one discovers that the geneticist cured his diabetes by changing his lifestyle and didn’t even look at his “omics” while doing so. It`s a shame he didn`t report his omics during the lifestyle change because there would undoubtedly have been significant changes in gene expression only by changing the environment with no drugs. Such a demonstration might encourage other people to make those lifestyle changes before taking drugs knowing that there are signficant effects on the expression of genes. In a personal communication Dr. Snyder said that he has the data and will publish it later.

Before the days of genomics when I was reviewing grant applications, any application that proposed to blindly measure thousands of variables hoping to find something  related to a disease or a macroscopic process was immediately rejected as a “fishing expedition”. But genomics is now big business. $Billions are being spent on it in the futile hope that a genetic silver bullet will be found for those diseases of self-destructive lifestyles that account for most of our morbidity and premature mortality. As Dr. Snyder has elegantly demonstrated, we need to first change lifestyles and then maybe worry about the genetics of whatever rare diseases remain.


Classic hype by the promoters of “omics”, short for genomics, proteomics and metabolomics. The underlying myth is that by measuring enough genes and their products something will be found that can be targeted with a genetic silver bullet and save us from our self-destructive lifestyles.


Dr. Snyder measured various gene products from day 0 to day 420 when he inexplicably stopped. He developed type 2 diabetes during a respiratory virus infection probably due to increased insulin resistance. He then realized he had to change his lifestyle and cut his calorie intake and exercised. By day 550 his blood glucose was back to normal. The cure of his diabetes had nothing to do with measuring his gene expression and everything to do with changing his environment.


Dr. Snyder developed two viral infections while monitoring his “omics” but inexplicably stopped measuring them 20 days after he developed type 2 diabetes. The heavy black bar indicates when he changed his lifestyle by eating less calories and exercising more during which time he only measured his blood glucose.

The Future is your DNA?

“The future is your DNA.” Who was the PR type at McGill who came up with that slogan? As we see above, Dr. Snyder, geneticist extraordinaire, has clearly shown that his future is his lifestyle. Everyone is born with a fixed genome. There are very rare diseases that are purely genetic in cause but the diseases that maim and kill most of the world’s population are primarily environmental. Our genomes are optimized to permit reproductive success in an environment of scarcity and borderline starvation and are not and never will be optimized to an environment of unlimited addictive  highly processed food, alcohol and other drugs. Any amount of “omics” will not change that basic fact. In addition, the genomics promoters gloss over the profound problem in trying to make a connection between a linear code and the three-dimensional organism produced from the code. The phenotype is the result of unfathomably complex, self-referrential signalling and, so except for some relatively rare diseases that can be linked to genetic errors, there is no direct connection of the genome to predilection to common diseases. That is why huge amounts of data must be collected and huge amounts of money spent to glean even a borderline connection. This is why a recent study published in Science by the AAAS, the same organization that publishes ScienceNow, mentioned above, concluded that “for 23 of the 24 diseases, the majority of individuals will receive negative test results, … [so] these negative test results will, in general, not be very informative, as the risk of developing 19 of the 24 diseases in those who test negative will still be, at minimum, 50 – 80% of that in the general population”. In other words common diseases are caused by environmental factors regardless of the genome. Your future is your lifestyle choices.

In the more than ten years since the human genome was sequenced there is zero evidence that anyone has lived any longer because of that effort, as intellectually satisfying as it was. In Western societies, what has significantly prolonged life in the last decade is reduction in cigarette smoking. But other legal addictions to prescription drugs, junk food and alcohol threaten to wipe out these gains. Dr. Levin pleads for gene sequencing to solve the mysteries of chronic diseases like atherosclerosis that causes heart attacks and most stokes. “Via genomics medicine will become a more personalized, predictive and preventative science.” Such talk makes for good politics and attracts huge expenditures from governments, such as the likes of Génome Québec. Governments hate having to tell the electorate to change those self-destructive lifestyles that are the proven cause of atherosclerosis and most cancers but love to be seen as pursuing superficially attractive but futile high-tech cures that will obviate the need to control those legal addictions to which the electorate is very attached.

Posted in atherosclerosis, diabetes, Type 2, diet, environment, exercise, food, genomics, junk food | Tagged: , | 1 Comment »

Horrifying Habit Heroes

Posted by Colin Rose on February 26, 2012

Has anyone ever objected to exposing kids to the evil doings of villains like The Joker, Lex LuthorCatwomen and Darth Vader who kill and maim thousands and demolish whole cities or planets? Very few. But just suggest that the lifestyle habits of kids could be improved by creating examples of a healthy lifestyle, like the Habit Heroes of Disney World, and their evil enemies, like Lead Bottom or The Glutton, and the self appointed protectors of the delicate juvenile mind, cultural relativists, and “experts” in obesity are scandalized. Were there any complaints from the children themselves or their parents?


“It’s so dumbfounding it’s unreal,” says Dr. Yoni Freedhoff, an assistant professor of family medicine at the University of Ottawa. “I just can’t believe somebody out there thought it was a good idea to pick up where the school bullies left off and shame kids on their vacation.” Freedhoff  thinks it’s terrible that “society does believe (weight control) is about willpower and calisthenics.” So what does he thinks causes obesity? Bad genes? Toxic chemicals? Lack of bariatric surgery? Sorry Yoni, it’s called the First Law of Thermodynamics. Energy can’t be destroyed. It has to go somewhere. Whatever calories one eats has to go into work or fat storage. As the creators of Habit Heroes and anyone else who knows a little science realizes, eating too many calories mostly due to junk food addiction is the cause of obesity. The sooner children learn this fundamental law of physics and its consequences, the better. If obese children and their obese parents are offended by a law of physics, we have no sympathy.

“Rebecca Scritchfield, an adjunct professor at George Washington University, said she was “disgusted” by the exhibit’s implication that weight is indicative of health, writing: “I would love to know what sickos thought this up.” It seems Dr Scritchfield hasn’t read the literature proving that obesity reduces life expectancy and contributes to a large number of chronic diseases like Type 2 diabetes, hypertension and atherosclerosis.

Is educating children that a law of physics mandates that they shouldn’t be eating junk food and not moving more traumatic than them imagining Darth Vader destroying a planet? Are the many obese among them being “bullied” and “shamed?” Should they never be told that obesity will shorten their lives? Is it soul-destroying or empowering to suggest that people have to take some responsibility for their actions?

Not surprisingly the exhibit lasted only 3 weeks before it was shut down and the web site was “down for maintenance.”

We very much doubt that this exhibit will ever re-open. Anything that they say that even hints that obese children or adult have the freedom to make choices that affect their health can be interpreted as “shaming” or “bullying”. Cultural relativism denies the existence of free will in any domain and demands that all problems of identifiable groups be blamed on “social injustice” ; no one should ever be blamed for the consequences of their actions.

What really puzzles us is that the directors of Disney World should take this altruistic decision to promote healthy habits, knowing that some of their clients, parents and children, might be offended by the implication that their habits need changing and possibly cutting into the junk food sales in the park. Maybe they have seen some of our photos of the massive obesity of many visitors to Disney World and decided they had to do something to counteract this image. Of course, they should have included the parents in their message.

Disney World


Posted in addiction, ccsvi, multiple sclerosis | Tagged: | 2 Comments »

Canadian Government Promises to Fund Junk Science to Appease Zamboni Cult

Posted by Colin Rose on June 29, 2011

from the CBC

It was inevitable that the federal government and its advisory committee would cave into the incessant political pressure of the Zamboni cult. The government is trying to appease the Zamboni zealots who have mercilessly intimidated politicians to fund “liberation” treatment, which is nothing more than high-tech faith healing. Unscrupulous politicians like Libby Davies and Kirsty Duncan have exploited the internet presence of the cult and the public’s sympathy for desperate people for political gain to make the government look uncaring and aloof when it was just trying to pursue the time-honoured scientific method of determining truth.

All that has changed since the advisory committee first recommended not to fund clinical trials was the introduction of a private members bill to mandate clinical trials. Obviously this spooked the government because it would have been forced to vote against the Zamboni cult and lose political capital with no political benefit. Scientists and politicians alike are being viciously slandered by the Zamboni cult using the tools of the internet. A neuroradiologist, Dr. Rubin, on the advisory committee even admitted that he remained unconvinced that Zamboni’s “CCSVI” existed but he still voted for trials of “liberation”. Clearly, the decision was politically motivated. The real scientists were tired of continuously being accused of pandering to pharmaceutical companies and threw in the towel.

Normally a staunch resister of blackmail, intimidation and appeasement in other areas, Prime Minister Stephen Harper should know better. Appeasement of totalitarians, terrorists and  self-righteous zealots signals weakness of resolve and only empowers them. Zamboni zealots want nothing less than publicly funded “liberation” on demand. Promise of trials will not satisfy them. When well-blinded controlled trials eventually show that “liberation” is useless, the cult will still demand public funding by claiming that the trials were biased and influenced by Big Pharma. They have a religious faith in “CCSVI”, revealed, scientifically absurd truth from their saviour, Paolo Zamboni, and nothing will persuade them otherwise. I have tried and have been mercilessly attacked on blogs and Facebook. Absolute faith in revealed truth will tolerate no criticism.

There is now ample evidence that Zamboni’s “CCSVI” does not exist as a disease and that “liberation” is a cruel hoax bilking desperate people out of their life savings. See blogs for details of the junk science behind “CCSVI”.

At any rate, it is doubtful that any good well-blinded controlled trial of “liberation” will ever get done, at least in Canada. When the Saskatchewan Health Research Foundation asked for grant applications for trials of “liberation” it received only one and even that one didn’t meet the scientific standards of the Foundation. No true scientist is going to make him or herself a laughing stock by attempting to treat a nonexistent disease and go down in history as another fool who believed the Zamboni myth.

Posted in ccsvi, junk science, liberation, Zamboni | Tagged: , , | 106 Comments »

Olivia Chow, Desperate Wife of NDP Leader, Promotes Junk Food Addiction

Posted by Colin Rose on April 16, 2011

Olivia Chow, wife of NDP leader, Jack Layton, has sunk to a new low her desperate attempt to be re-elected in the riding of Trinity-Spadina after winning by only 3500 votes in 2008. She is paying for the distribution of mini ice cream cones to attract and bribe voters. Ice cream is the quintessence of junk food, a concoction of sugar and fat that has been perfected over many years to appeal to those addictions. The money to pay for this promotion of addiction is coming from donations to the NDP. Obviously the NDP doesn’t care that the consequences of junk food addiction, obesity, Type 2 diabetes, knee osteoarthritis, high “cholesterol” and high blood pressure, account for the most of the exorbitant increases in spending on “health care.”

From MacLean’s

From the Star

Posted in addiction, Canada, diabetes, Type 2, health care, junk food, obesity | Tagged: | Leave a Comment »

The Cardiometabolic Risk Working Group: Another Coven Practising Drug-Induced Magical Thinking

Posted by Colin Rose on April 14, 2011

The latest issue of the Canadian Journal of Cardiology, published by the Canadian Cardiovascular Society (CCS), both of which are largely funded by the drug industry has shamelessly published a “Position Statement by the Cardiometabolic Risk Working Group” (see highlights below). We have previously blogged about the American “Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults” and the Canadian “Working Group on Hypercholesterolemia and Other Dyslipidemias”. Now that the ability of “cholesterol” to induce terror in doctors and patients has become a little worn and less profitable, drug dealers have invented a new disease, “cardiometabolic risk” with which to terrorize asymptomatic people into demanding even more drugs and doctors into prescribing them. Many of the members of the previous covens have migrated to the new one.

These medical covens take it upon themselves to dictate to the rest of the medical profession what drugs should be prescribed to prevent diseases of lifestyle in the otherwise “normal” population, so-called primary prevention. How are these covens assembled and what gives them the authority to establish norms for other doctors? This paper reveals in stunning clarity the answers to these questions. As we can see from the Acknowledgements and Disclosures sections, most of the authors of this Position Statement have many long-term financial relations with many drug dealers. Of the ten members of the executive committee of the Cardiometabolic Risk Working Group, nine have multiple financial relations with drug dealers and of the whole Working Group 19 out of 21 have similar relations. Clearly, drug dealers have distributed tens, if not hundreds, of millions of dollars to these doctors, justified under various guises, to facilitate a culture of drug dependency. Drug dealers choose members of  the Working Group, pay them to be “authors”, pay a medical writer to compose the Position Statement and get it published in a journal which would not exist without the financial support of the same drug dealers. Why am I not impressed and why would any other doctor follow the advice of this coven? But most family physicians and many cardiologists treat this sort of statement, endorsed by presumably unassailable organizations like the CCS, as revealed truth by a mysterious higher authority in possession of occult knowledge that must be accepted or suffer ostracism by one’s colleagues. Of course it doesn’t hurt that a 30-second drug prescription for numerical symptoms of junk food addiction is much easier that spending many unpaid hours reducing the addiction, the only real way to prevent its consequences.

Here is an example of the occult numerological incantations of the Working Group. Compare this with the occult number philosophy of Agrippa based on the pentacle below.

Optimize lipid levels. In patients with cardiometabolic risk with a moderate or high Framingham Risk Score, treatment should be initiated with a statin to reduce low-density lipoprotein cholesterol (LDL-C) by at least 50% and to 2.0 mmol/L. Apo B levels are a better measurement of lipid-related risk in these patients, and the target level for treatment is 0.8 g/L in high-risk and moderate-risk individuals. There is a large residual risk for patients at high risk for CVD, despite LDL-C reduction with high-dose statins. Many patients with cardio- metabolic risk may also have an acquired combined hyperlipidemia, associated with increased triglycerides (TGs), a modest increase in LDL-C, and low high-density lipoprotein cholesterol (HDL-C). LDL particle numbers are increased, as reflected by the increased levels of apo B100. Beyond LDL-C lowering, strategies that might reduce the residual risk include reducing the total cholesterol (TC) to HDL-C ratio, high-sensitivity C-reactive protein, and TG, although there are no clinical trial data to date to support such strategies. In the patient with diabetes, glycemic control optimization and health behaviour modification should be attempted prior to the addition of another agent, such as a fibrate. In the Action to Control Cardiovascular Risk in Diabetes trial the addition of fenofibrate to simvastatin in patients with type 2 diabetes failed to show any reduction of CV events, although there may have been benefit in the subset of individuals with high TG/low HDL-C.

The deliberations of the Cardiometabolic Risk Working Group have much in common with pagan covens with occult rituals and symbols like the pentacle which when worn will drive out evil numbers such as “cholesterol”. Expensive statins for “cholesterol” and ARBs for high blood pressure are the new pentacle. The significance of the pentacle, as described by Heinrich Cornelius Agrippa in his Three Books of Occult Philosophy, makes as much sense as the Position Statement of the Working Group.  “A Pentangle also, as with the vertue of the number five hath a very great command over evil spirits, so by its lineature, by which it hath within five obtuse angles, and without five acutes, five double triangles by which it is surrounded. The interior pentangle containes in it great mysteries, which also is so to be enquired after, and understood; of the other figures, viz. triangle, quadrangle, sexangle, septangle, octangle, and the rest, of which many, as they are made of many and divers intersections…

When one manages to decode the occult numerology of the Statement one can see that the goal of the Working Group is to have every overweight junk-food addict in Canada, the typical “high-risk” patient, on some combination of pills for “high” blood pressure and “high” cholesterol. The “targets” for blood pressure and cholesterol are set low and arbitrarily to guarantee that most of the Canadian population would be on some drug. The drug dealers can be assured that doctors will prescribe the newest, most expensive patented drug rather than a cheaper generic alternative because they have already spend hundreds of millions of dollars in advertising the advantages of the patented drugs. This is called clever marketing but it has nothing to do with the health of the population. The consequences of self-destructive lifestyles will not be lessened by any number of drugs which will have the unintended consequence of worsening those lifestyles when people are convinced they can continue those lifestyles with impunity under the “protection” of drugs that make the numerical symptoms of those lifestyles look better. While the Position Statement gives lip service to the necessity of “health behaviour interventions” it insists also on the necessity of “vascular protective measures”, code for expensive drug prescription.

Canada is currently in the middle of a federal election campaign in which the most important issue for voters is “health care”. All parties are promising to increase “health care” spending by 6% a year indefinitely. With an inflation rate of only 2%, a PhD in mathematics is not required to see that in the not too distant future “health care” will consume the entire tax revenue of federal and provincial governments. The increase in “health care” spending is driven by the sort of activities represented by this Position Statement but no candidate dares to mention drug-induced magical thinking in their campaign speeches or platforms. The electorate loves its addictions and demands infinite “health care” to provide the mirage of protection from the consequences of those addictions and any candidate who points out the obvious absurdity of this belief is dead electoral meat.

How can we exorcise the myths promoted by these venal covens? There at two excellent drug review publications written by authors with absolutely no connection to drug dealers that should be required reading for every doctor: Prescrire, a French publication available in English, which is expensive but is the gold standard in independent thinking about drugs and the Drug and Therapeutics Bulletin of Navarre, a Spanish publication, available in English, which is free but covers a limited range of drugs. A recent excellent article from the latter, “Magical numbers in pharmacological prevention of cardiovascular disease and fractures: a critical appraisal“, analyzed in detail the occult numerology of the drug-funded covens’ pontifications on “primary prevention” and concludes,

A considerable part of the pharmacological recommendations to prevent cardiovascular events and fractures in healthy persons lack any solid justification. No clear efficacy, nor the size of the effect of these agents or a clear balance between risk and benefit make the intervention clinically and socially worthwhile. The “therapeutic targets” and the “operative definition” of disease or risk factor that include instruments or tables to calculate risk are new gateways to unnecessary medicalization. In the context of modern medicine, immersed in conflicts of interest, the physician is obliged to interpret the results of trials and the recommendations from guidelines and consensus at a critical distance, and to place emphasis on the development of clinical prudence as a desired skill.

In other words a truly professional doctor will ignore any advice from the drug dealer funded covens and use his or her own best judgement.

Lawrence A. Leiter, David H. Fitchett, Richard E. Gilbert, Milan Gupta, G. B. John Mancini, Philip A. McFarlane, Robert Ross, Hwee Teoh, Subodh Verma,  Sonia Anand, Kathryn Camelon, Chi-Ming Chow, Jafna L. Cox, Jean-Pierre Després, Jacques Genest, Stewart B. Harris, David C. W. Lau, Richard Lewanczuk, Peter P. Liu, Eva M. Lonn, MD, Ruth McPherson, Paul Poirier, Shafiq Qaadri, Rémi Rabasa-Lhoret, Simon W. Rabkin, Arya M. Sharma, Andrew W. Steele, James A. Stone, Jean-Claude Tardif, Sheldon Tobe, Ehud Ur

Posted in Canada, cardiology, cholesterol, cme, continuing medical education, diabetes, diabetes, Type 2, diet, drug marketing, drugs, election, ethics, health care, junk food, medical terrorism, obesity, professionalism, statins | 5 Comments »

“The perfect crime? CCSVI not leaving a trace in MS” – “Liberation” is a hoax

Posted by Colin Rose on February 4, 2011

Just published today, is a report of the first independent investigation by Christopher Mayer, et al from Germany with no connection to drug companies that attempts to use Zamboni’s Doppler technique for diagnosing “CCSVI” but in a rigorously controlled and blinded manner.

Conclusion: “This triple-blinded controlled study does not support insufficient extra- and intracranial venous flow in MS. Together with two other recent studies, this constitutes compelling evidence against a significant contribution of CCSVI to the pathogenesis of MS. As interventional procedures such as transluminal angioplasty are derived from the non-confirmed CCSVI concept and can result in serious adverse events, we strongly discourage the use of these procedures on the grounds of the present evidence.”

At least four blinded studies using magnetic resonance venography came to the same conclusion.

This is what we predicted in November, 2009 when Zamboni’s “breakthrough” was first announced by the scoop-hungry media. The absurdity of the concept was quite obvious but emotional YouTube videos of instantaneous improvement in symptoms overwhelmed rational thought.

Face it, true believers. No blinded study using any technique has been able to reproduce Zamboni’s data. Zamboni succumbed to irrational self deception in a futile attempt to cure his wife’s MS. “CCSVI” doesn’t exist. All “liberation” factories should be shut down, now. Any doctor who continues to do “liberation” should lose his or her license to practice.

If nothing else of use results from the Zamboni fad, which has cost patients, charities and governments at least $one billion, we should have learned a number of lessons:

  • the absolute necessity for careful blinding of clinical trials before a paper on them is accepted by any medical journal.
  • the necessity for regulation of surgical procedures in the same way as drugs are regulated.
  • the necessity for ethical doctors to increase their presence in the internet social media to counteract patient hysteria and the venality of some members of their profession.
  • before media reporters are allowed to report on medical and scientific topics must take a course in assessment of the validity of publications in journals.
  • in this internet age, high school science education, in addition to the standard curricula, needs to teach skills in the assessment of the validity of data and conclusions drawn from them, using the Zamboni fad as a classic example of what not to do.

The fad has also put a focus on the powerful effects of faith healing on the symptoms of MS as seen in this video.

Exactly the same instantaneous “cures” are shown in numerous post “liberation” videos. Faith in modern technology, pseudo-science and surgeons is replacing faith in the traditional saviours. The psychology underlying faith healing in MS needs investigation. Because of the intermittent and prolonged nature of the disease, MS patients are particularly prone to faith healing, when they are given some hope for the future. There seem to be a lot of MS patients whose symptoms are to some degree subconsciously self-inflicted out of depression or to attract sympathy who could be helped with the right form of psychotherapy.

Posted in ccsvi, faith healing, liberation, multiple sclerosis, Zamboni | 68 Comments »

MS patients have normal intracranial pressure-Zamboni’s “CCSVI” does not exist, “liberation” is futile

Posted by Colin Rose on February 3, 2011

Paolo Zamboni must be getting just a little nervous over the continuing failure of any other investigator to find the slightest evidence for “CCSVI”, his purported venous “reflux” that could only damage the brain by causing an increase in intracranial pressure. The latest is a report by Rolf Meyer-Schwickerath, et al., using the elegant, noninvasive technique of measuring venous occlusion pressure, who showed that intracranial pressure in MS patients is perfectly normal, but increased in patient with known causes of increased intracranial pressure. These observations confirm previous studies using magnetic resonance venography showing that MS patients have the same wide variation in head and neck venous anatomy as normal people. As we have explained in our original post on “CCSVI” even total occlusion of both internal jugular veins does not result in increased venous pressure of increased intracranial pressure due to the extensive venous collateral circulation from the head.

Their conclusion:  “In summary, there is no evidence of an increase in intracranial venous pressure in our MS patients due to a CCSVI mechanism in MS. Our findings do not justify operative procedures.” In other words, Zamboni’s “liberation” treatment for MS is useless.

To date, at least $one billion has been wasted on Zamboni’s seductive myth. When will the medical profession start policing itself and shut down all the venal charlatans deceiving desperate MS patients and their families into depleting their savings to have “liberation”?

Posted in ccsvi, liberation, Zamboni | 1 Comment »

Paolo Zamboni-Medical Con Man Supreme-Patenting a Disease

Posted by Colin Rose on January 26, 2011

When I first heard about Paolo Zamboni’s miraculous surgical “cure” for multiple sclerosis, I had supposed, that in addition to his desire to treat in wife’s MS, he was motivated by the delusion that he could earn a place in the medical pantheon, alongside Jenner, Salk, Banting etc. Only after viewing various internet postings has it become clear to me that Zamboni  plans to make himself a billionaire by patenting a disease, “CCSVI”, and the means to diagnose it. He realizes that he can’t patent the “liberation” procedure which is now done by dozens of avaricious, unscrupulous surgeons around the world but he can patent the machinery to diagnose the condition for which “liberation” is the treatment.

In 2008 he applied for a US patent for a “System for Diagnosing Multiple Sclerosis”.  Note that there is no mention of his employer, the University of Ferrara anywhere in the application. If the University had considered “CCSVI” to be a significant innovation it would surely have insisted on applying for the patent as is its right. Also, note that he does not claim just to be diagnosing “CCSVI” or just neck vein abnormalities. Apologists for Zamboni often claim that he is only diagnosing “CCSVI” and only secondarily MS. To quote: “An embodiment of the invention is a system for diagnosing multiple sclerosis based on the determination of the rate of reflux, increased indices of resistance in the cerebral veins for providing clinical data useful for diagnosing multiple sclerosis.”

At the same time Zamboni is acting as a consultant to Esaote, a Genoa-based manufacturer of ultrasound equipment which is selling the only machine approved by Zamboni for diagnosing “CCSVI”. No doubt Zamboni envisions this machine being bought by the thousands, if not tens of thousands by radiology departments in hospitals around the world to screen for “CCSVI” in everyone under age 40 so that they can  be treated for “CCSVI” by his “liberation” procedure and presumably prevent MS. Curiously, the description of this machine only appears in the site of the Bulgarian purveyor of “liberation” not in Esaote’s own site. I suspect that Esaote doesn’t want to publicize the use of transcranial Doppler for studying intracranial veins with the Zamboni machine because this technique has never been validated and is not used in legitimate ultrasound labs. Transcranial Doppler has a few uses for looking at cerebral arterial blood flow that do not include trying to image venous flow which would be hard to distinguish from arterial flow, as recommended by the US Agency for Healthcare Research and Quality.

“Settings in which transcranial Doppler ultrasonography (TCD) is able to provide information and in which its clinical utility is established.

  1. Screening of children aged 2 to 16 years with sickle cell disease for assessing stroke risk (Type A, Class I), although the optimal frequency of testing is unknown (Type U).
  2. Detection and monitoring of angiographic vasospasm (VSP) spontaneous subarachnoid hemorrhage (sSaH) (Type A, Class I-II). More data are needed to show if its use affects clinical outcomes (Type U).”

TCCS: “transcranial color-coded duplex sonography”, ECD: “extracranial EchoColor-Doppler”. These two forms of imaging are somehow combined by the special software in the  PC to diagnose “CCSVI”. In other words, this disease can only be diagnosed with Zambonis machine. Zamboni is attempting to patent a disease.

Of course, the only way one can learn to use the Zamboni “CCSVI” machine is to take special training from the master himself or from one of his franchises. The Hilarescere Foundation is Zamboni’s charity, the scientific committee of which doles out money to him and his friends.

Unfortunately for him, Zamboni is unlikely to make much from his machine. Most of the charlatans around the world doing “liberation” don’t bother to do transcranial Doppler to document “reflux” in intracranial veins. Too much hassle. Like Marian Simka in Poland, the scammers just do a fast scan of neck veins with  regular Doppler that shows pulses on the screen and makes swishing noises which seems  to be enough to convince the desperate patient that he/she needs “liberation” @ $10,000. Note that Simka is not doing transcranial Doppler, just neck scanning with a small portable Doppler machine. And there is certainly no computer in sight  to analyze the data as required  by the Zamboni patent application. This patient is even demanding to have stents inserted [more money], so fearful is he of having a “restenosis” and not being able to afford to return to Poland for another “liberation.”

Here is a Zamboni machine that isn’t a hoax.

Posted in angioplasty, ccsvi, junk science, liberation, multiple sclerosis, Zamboni | 4 Comments »