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Archive for the ‘exercise’ Category

Geneticist Cures His Own Type 2 Diabetes by Changing his Lifestyle not his Genes

Posted by Colin Rose on April 15, 2012

This story in Science Now, a vehicle published by the AAAS for vulgarization of  basic science, is a classic example of the hype surrounding gene sequencing and gene expression. To judge from this headline any reader would assume that the cure for Type 2 diabetes was simply to measure genes and gene expression. However when one reads the actual publication one discovers that the geneticist cured his diabetes by changing his lifestyle and didn’t even look at his “omics” while doing so. It`s a shame he didn`t report his omics during the lifestyle change because there would undoubtedly have been significant changes in gene expression only by changing the environment with no drugs. Such a demonstration might encourage other people to make those lifestyle changes before taking drugs knowing that there are signficant effects on the expression of genes. In a personal communication Dr. Snyder said that he has the data and will publish it later.

Before the days of genomics when I was reviewing grant applications, any application that proposed to blindly measure thousands of variables hoping to find something  related to a disease or a macroscopic process was immediately rejected as a “fishing expedition”. But genomics is now big business. $Billions are being spent on it in the futile hope that a genetic silver bullet will be found for those diseases of self-destructive lifestyles that account for most of our morbidity and premature mortality. As Dr. Snyder has elegantly demonstrated, we need to first change lifestyles and then maybe worry about the genetics of whatever rare diseases remain.

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Classic hype by the promoters of “omics”, short for genomics, proteomics and metabolomics. The underlying myth is that by measuring enough genes and their products something will be found that can be targeted with a genetic silver bullet and save us from our self-destructive lifestyles.

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Dr. Snyder measured various gene products from day 0 to day 420 when he inexplicably stopped. He developed type 2 diabetes during a respiratory virus infection probably due to increased insulin resistance. He then realized he had to change his lifestyle and cut his calorie intake and exercised. By day 550 his blood glucose was back to normal. The cure of his diabetes had nothing to do with measuring his gene expression and everything to do with changing his environment.

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Dr. Snyder developed two viral infections while monitoring his “omics” but inexplicably stopped measuring them 20 days after he developed type 2 diabetes. The heavy black bar indicates when he changed his lifestyle by eating less calories and exercising more during which time he only measured his blood glucose.

The Future is your DNA?

“The future is your DNA.” Who was the PR type at McGill who came up with that slogan? As we see above, Dr. Snyder, geneticist extraordinaire, has clearly shown that his future is his lifestyle. Everyone is born with a fixed genome. There are very rare diseases that are purely genetic in cause but the diseases that maim and kill most of the world’s population are primarily environmental. Our genomes are optimized to permit reproductive success in an environment of scarcity and borderline starvation and are not and never will be optimized to an environment of unlimited addictive  highly processed food, alcohol and other drugs. Any amount of “omics” will not change that basic fact. In addition, the genomics promoters gloss over the profound problem in trying to make a connection between a linear code and the three-dimensional organism produced from the code. The phenotype is the result of unfathomably complex, self-referrential signalling and, so except for some relatively rare diseases that can be linked to genetic errors, there is no direct connection of the genome to predilection to common diseases. That is why huge amounts of data must be collected and huge amounts of money spent to glean even a borderline connection. This is why a recent study published in Science by the AAAS, the same organization that publishes ScienceNow, mentioned above, concluded that “for 23 of the 24 diseases, the majority of individuals will receive negative test results, … [so] these negative test results will, in general, not be very informative, as the risk of developing 19 of the 24 diseases in those who test negative will still be, at minimum, 50 – 80% of that in the general population”. In other words common diseases are caused by environmental factors regardless of the genome. Your future is your lifestyle choices.

In the more than ten years since the human genome was sequenced there is zero evidence that anyone has lived any longer because of that effort, as intellectually satisfying as it was. In Western societies, what has significantly prolonged life in the last decade is reduction in cigarette smoking. But other legal addictions to prescription drugs, junk food and alcohol threaten to wipe out these gains. Dr. Levin pleads for gene sequencing to solve the mysteries of chronic diseases like atherosclerosis that causes heart attacks and most stokes. “Via genomics medicine will become a more personalized, predictive and preventative science.” Such talk makes for good politics and attracts huge expenditures from governments, such as the likes of Génome Québec. Governments hate having to tell the electorate to change those self-destructive lifestyles that are the proven cause of atherosclerosis and most cancers but love to be seen as pursuing superficially attractive but futile high-tech cures that will obviate the need to control those legal addictions to which the electorate is very attached.

Posted in atherosclerosis, diabetes, Type 2, diet, environment, exercise, food, genomics, junk food | Tagged: , | 1 Comment »

Sly children fool exercise study

Posted by Colin Rose on July 13, 2009

Like alcoholics, junk food addicts will lie to conceal their addiction. All studies of obesity that rely on self-reporting of calorie intake or expenditure are useless.

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From the BBC

Children taking part in a study to measure how much exercise they do fooled researchers by attaching their pedometers to their pet dogs.
About 200 children in east London were given pedometers to automatically count how many steps they walked and ran.


Mile End Centre for Sports and Exercise Medicine was surprised by the activity levels recorded in some obese children.
Professor Nicola Maffulli said: “Then we realised they were attaching the pedometers to their dogs’ collars.”
‘Extremely active’
The pilot study in Whitechapel required 11 and 12-year-olds to clip a pedometer to their waists, with researchers at the centre collecting the readings by satellite.
“But after a week we found there were some kids who were extremely active but still obese,” said Professor Maffulli.
It was “not unheard of” for participants in previous studies to manipulate the readings of pedometers, he added.
Once adjusted to take into account the help from pets, the study indicated that boys in the borough walk or run 12,620 steps a day, below the recommended level of 15,000 steps.
It also found that girls take 10,150 steps, falling short of the recommended 12,000 steps.
It indicated that more than a third of 11 and 12-year-olds in the borough of Tower Hamlets are overweight or obese – 11% higher than the national average.
Researchers plan to extend the study to include more children in the borough.

Posted in addiction, exercise, obesity | Tagged: , | Leave a Comment »

A TO Z trial. Atkins tops?

Posted by Colin Rose on March 12, 2007

The recent publication of the results of the A TO Z trial of four weight-loss “diets” made headlines around the world: “ATKINS DIET TOPS”. The group on the Atkins diet lost about 10 pounds, a few more pounds than the others, after one year of “dieting”.

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Did anyone, including the paper’s reviewers, actually look at the numbers behind this conclusion? Table 1 shows the baseline parameters.

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Note that the average BMI was about 32. One is considered to be obese above a BMI of 30. So most were obese. Note also the weights. About 85 kg. Now look at the results in Table 2 (below). Remember that these numbers are derived by SELF REPORTING of food consumption and exercise. The subject could tell the investigators anything. There was no check on what they said. They were paid, so the subjects had an incentive to the investigators what the subjects thought the investigators wanted to hear. The subjects claimed to be eating about 1900 kcal/day at the outset of the trial. Any adult who eats only 1900 kcal/day is UNLIKELY TO GET OBESE in the first place. During the trial they claimed to be eating only about 1500 kcal/day. So even if they hadn’t increased exercise they should have had a deficit of 400 kcal/day, 2800 kcal/wk. One pound of fat is about 3500 kcal. So, if we are to believe what they reported, they should have lost at least 3 pounds per month or 36 pounds per year. But even the Atkins group only lost 10 pounds. It gets worse. They reported total energy expenditure of about 35 kcal/kg/day. Multiply by their weight and you get about 3000 kcal/day. But they claimed to be eating only 1500 kcal/day. So they should have lost two to three pounds per week, at least 100 pounds per year. Also note that total calorie intake remained about the same in all groups in spite or a wide range of percentages of protein, fat and carbohydrate and by the end of the trial these percentages tended towards the same fraction in all groups. The First Law of Thermodynamics says energy cannot be created or destroyed. Any study of energy flows that cannot first show that energy is conserved should never be published. The methods employed by the study are fatally flawed. No conclusion can be drawn from this data. Many interpretations are possible. So, if all groups ate the same REPORTED calories on the average and burnt the same REPORTED calories on average, why did the Atkins group lose a little more weight? Maybe the Atkins group did a little more exercise. Who knows? They were lying about everything. Or, maybe, for some reason those presumably following the Atkins diet were slightly less proficient liars as the others.

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That obese people lie about food intake was proven beyond doubt by a study using doubly-labeled water to measure true energy expenditure. About 65% of these subjects were overweight or obese. They claimed to be eating only about 1500 kcal/day but were burning 2500. So, they should have had a deficit of 1000 kcal/day and be losing weight dramatically but their weights were stable. Ergo they were “misreporting”, a euphemism for lying.

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The real cause of obesity is food addiction. Like alcoholics food addicts will deny they consume too much and/or exercise too little. See my photo essay on the topic. Which diet is this lady on?

Food Addiction

Is she on a low-fat or low-carb diet?

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