The ASCOT-LLA Trial
ASCOT-LLA is another oft-quoted trial purporting to show that statins are the cure for atherosclerosis.
Again, in order to show the slightest effect the investigators went to, you guessed it, Northern Europe, not Northern Ethiopia. Note, in particular that all patients had major lifestyle problems before the trial. At this point investigators had totally given up on trying to change lifestyles before the trial, making the trial highly unethical. It should never have been published.
Here are the details underlying the yellow-highlighted sections of the abstract.
Note average BMI of patients was 28.6. A BMI of 25 or over is overweight and over 30 is obese. So ALL study patients were overweight or obese, a major risk factor for atherosclerosis which should have been eliminated before the trial. To perform a drug trial for a disease of lifestyle without optimizing lifestyle first is unethical and contrary to the Hippocratic Oath.